Our proprietary biosensors rely on organic electrochemical transistors (OECTs), an amplifying transducer pioneered by Prof. George Malliaras. Traditional electrochemical biosensors use passive electrodes, measuring signals directly from binding. Transistor biosensors amplify these signals on-site, producing large signal modulations even from tiny input currents. OECTs offer uniquely affordable, scalable manufacturing because the conducting polymer channel is solution processable. The organic channel can be de-doped throughout its entire volume, leading to very high amplification (transconductance) in comparison to field-effect transistors.

Bainbridge Bio’s OECT platform unlocks a highly sensitive and miniaturized signal readout from redox-modified aptamers – a specific and modular biorecognition strategy. On-site amplification lets us shrink the devices down, for high data quality even on the micro-scale. The aptamer-based transistor (AB-OECT) is a uniquely enabling platform for multiplexed sensing in small volumes.

Read more about the technology here.